Aciclovir 400mg 1 Tablet [PRESCRIPTION REQUIRED]

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For the treatment of herpes simplex virus (Type 1 and Type 2) infections of the skin and mucous membranes including initial and recurrent genital herpes, herpes zoster (shingles) infections, chickenpox (varicella) infections in children over the age of two years

Place of Origin

South Korea

Product Usage

DOSAGE IN ADULTS: Treatment of Herpes simplex infections: 200mg should be taken 5 times daily at approximately 4-hourly intervals omitting the night time dose. Treatment should continue for 5 days, but in severe initial infections this may have to be extended. In severely immunocompromised patients or in patients with impaired absorption from the gut, the dose can be doubled to 400mg or alternatively intravenous dosing could be considered. Dosing should begin as early as possible after the start of an infection; for recurrent episodes this should preferably be during the prodromal period or when lesions first appear. Suppression of herpes simplex infections in immunocompromised patients: 200mg should be taken 4 times daily at approximately 6-hourly intervals. Many patients may be conveniently managed on a regimen of 400mg twice daily at approximately 12-hourly intervals. Dosage titration down to 200mg taken thrice daily at approximately 8-hourly intervals or even twice daily at approximately 12-hourly intervals, may prove effective. Therapy should be interrupted periodically at intervals of 6-12 months, in order to observe possible changes in the natural history of the disease. Prophylaxis of herpes simplex infections in immunocompromised patients: 200mg should be taken 4 times daily at approximately 6-hourly intervals. In severely immunocompromised patients or in patients with impaired absorption from the gut, the dose can be doubled to 400mg or alternatively, intravenous dosing could be considered. The duration of prophylactic administration is determined by the duration of the period of risk. Treatment of herpes zoster infections: 800mg should be taken 5 times daily at approximately 4-hourly intervals omitting the night time dose. Treatment should continue for 7 days. In severely immunocompromised patients or in patients with impaired absorption from the gut, consideration should be given to intravenous dosing. Dosing should begin as early as possible after the start of an infection; treatment yields better results if initiated as soon as possible after rash onset. DOSAGE IN

CHILDREN: Treatment of herpes simplex infections and prophylaxis of herpes simplex infections in tthe immunocompromised: Over 6 years old: Aciclovir should be given 800mg 4 times daily. 2-5 years old: Aciclovir should be given 400mg 4 times daily. Less than 2 years old: Aciclovir should be given half the adult dose or 200mg 4 times daily. No specific data are available on the suppression of herpes simplex infections in immunocompetent children. Treatment of chickenpox in children up to 2 years old: Aciclovir is administered 20mg/kg on the basis of body weight 4 times daily for 5 days. Dosing should begin as early as possible after the start of a chicken pox rash, treatment yields better results if initiated within 24 hours after rash onset.

Ingredients

ACICLOVIR 400MG

Warnings

CONTRAINDICATIONS: Aciclovir is contraindicated in patients known to be hypersensitive to the drug.

PRECAUTIONS: Aciclovir should be administered with caution to patients with renal impairment and doses should be adjusted according to creatinine clearance. The risk of renal impairment is increased by the concomitant use of other nephrotoxic drugs. USE IN PREGNANCY AND LACTATION: Aciclovir is distributed into breast milk following oral adminsitration. A dose of 200mg five times daily could expose a suckling infant to 300mcg per kg body weight daily; caution is therefore recommended when treating breastfeeding mothers. Adminsitration of Aciclovir produces embryotoxic or teratogenic effects in rats

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